Ion Exchange (IEX) media
Ion Exchange (IEX) chromatography media is popularly employed to separate molecules, such as large proteins, small nucleotides and amino acids etc, based on their charge. The functional groups in IEX media have charges that bind molecules with opposite charges. Release of the bound molecules from the medium is achieved by displacement, via the application of an increasing concentration of a similarly charged molecule.
By design of the bead size, pore size, functional groups and the mechanical strength of individual base matrices, our IEX media can be used for capture of bulk product or impurities from large-volumes, as an intermediate purification step, or as a final step for high resolution purifications.
We offer an extensive range of ion exchange chromatography media (resins) in lab packs, bulk quantities and pre-packed columns. Each range of IEX media has a choice of Q (strong anion-exchange), SP (strong cation-exchange), DEAE (weak anion-exchange) and CM (weak cation-exchange). Depending on the nature of your application, the property of your feedstock and the resolution you need, the general selection guide is shown below:
- IEX Selection Kits contain pre-packed 1 ml columns good for fast preliminary screening of different IEX resins.
- IEX SepFast 6HF range has 50-150 µm bead size offering general cost-effective bioprocessing use.
- IEX SepFast 6HF Plus range has 50-150 µm bead size offering increased dynamic binding capacity than IEX SepFast 6HF.
- IEX SepFast HighRes range has 20 -50 µm bead size offering high resolution purification power at reasonable cost.
- IEX SepFast HighRes Plus range has 20 -50 µm bead size offering increased dynamic binding capacity than IEX SepFast HighRes.
- IEX SepFast Large Beads range has 100-350 µm bead size and is designed for processing particular-containing feeds or for processing very high volume of materials at very high flowrates.
- IEX SepFast Large Beads Plus range has 100 - 350 µm bead size offering increased dynamic binding capacity than IEX SepFast Large Beads.
- SepFast DUO range of IEX media (150, 400, 700, 5000, 6000, 7000, 8000, 9000 and 10000) is a unique class of resins based on shelled-bead technology that combines selective size exclusion shell and IEX core to a single bead. This class of IEX media can purify molecules based on size and charge at the same time, showing great applications in purifying almost all types of biological materials (e.g. antibodies, enzymes, DNA, RNA, viruses, exosomes etc).
- SepFast Macro is suitable for purifying pegylated molecules.
- SepFast Supor range is good for capturing nanoparticles (plasmids, viruses etc) with decent binding capacity, alternative to membrane chromatography.
- SepFast Ultra range allows high resolution purification (such as purifying oligonucleotides) at increased pressure (up to 20 bar) or increased temperature.
- Magnetic IEX media range offers very cost-effective and efficient high-throughput screening applications in drug discovery field.
Ion Exchange (IEX) media products
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IEX Selection Kit
£238.99 – £262.89 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast 6HF
£66.03 – £1,350.80 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast 6HF Plus
£116.01 – £1,350.80 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast HighRes
£138.37 – £1,851.30 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast HighRes Plus
£160.72 – £2,036.43 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast Large Beads
£66.03 – £1,038.40 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
IEX SepFast Large Beads Plus
£116.01 – £1,218.80 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 150
£95.29 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 5000
£95.29 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 6000
£189.31 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 7000
£189.31 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 8000
£189.31 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 9000
£189.31 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast DUO 10000
£189.31 – £2,359.50 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast Macro
£193.12 – £2,475.66 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast Supor
£186.51 – £960.74 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
SepFast Ultra
£85.00 – £2,806.00 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page -
Magnetic IEX Media
£113.00 – £1,126.40 ex. VAT Select options This product has multiple variants. The options may be chosen on the product page